Endocrine Abstracts

Transsphenoidal pituitary surgery is the method of choice in the treatment of ACTH-DCS, although to date, according to a number of researchers, the method is not ideal. Despite the achievement of immediate postoperative remission in 69-98% of cases, with an increase in the duration of follow-up after TSS from 5 to 10 years, an increase in the frequency of relapses from 15 to 66% is observed. In this regard, we analyzed cases of ACTH DCS subjected to TSS for 2003-2021, included...

Hypercorticism is a syndrome caused by extended and very high exposure of glucocorticoids to the body. ACTH-dependent Cushing’s syndrome develops as a result of the overproduction of adrenocorticotropic hormone by the pituitary adenoma. The main treatment for ACTH-dependent Cushing’s is transnasal transsphenoidal removal of the pituitary adenoma. A the same time, the recurrence rate of Cushing syndrome is observed up to 3% during the year and up to 3% –22% of...

Cushing’s is a challenging disease to diagnose. The diagnosis is often delayed because Cushing’s is frequently masked by its overlap with more common medical problems such as diabetes, high blood pressure, obesity and polycystic ovary syndrome. Cushing’s may be more common than previously thought. The patient is a 15-year-old girl who developed symptoms of hyperandrogenia about 3 years prior to her visit to the Endocrine medical research Center, Uzbekistan. The ...